Studies

EXCALIBUR-HFpEF

A study for people with heart failure with preserved ejection fraction (HFpEF). It investigates how a personalised training programme and app-based activity coaching affect physical activity and cardiovascular fitness, compared with standard care.

Personalised training

A training programme tailored to each participant together with sports-medicine specialists, designed to fit into everyday life.

Digital activity coaching

A digital concept records everyday movement and can provide motivating prompts. It was previously used in the MyoMobile study.

Research data

Medical data and biomaterials are collected to build a biodatabase for future heart-failure research and new AI methods.

Who is behind it

Researchers at University Medical Center Mainz and Heidelberg University Hospital, funded by the Carl-Zeiss-Stiftung as part of Multi-dimensionAI.

  1. Preliminary assessment and eligibility review
  2. Movement monitor worn for one week
  3. Random allocation and comprehensive medical assessment
  4. Individual training-plan instruction (intervention group)
  5. Telephone check-ins after 4 and 8 weeks
  6. Repeat movement monitoring from week 11
  7. Final visit and repeat medical assessment after 12 weeks

On request, participants receive the results of their examinations.

  • Aged 45 or older
  • Diagnosed heart failure with a left ventricular ejection fraction (LVEF) above 40 %
  • No shortness of breath at rest (breathlessness during physical exertion is possible)
  • No change to cardiovascular medication in the last 4 weeks
  • No active cancer currently treated with chemotherapy or radiotherapy

The study team checks all criteria at the preliminary assessment.

Heidelberg

Heidelberg University Hospital · Department of Cardiology, Angiology and Pneumology

  • Prof. Dr. Norbert FreyStudy lead
  • Prof. Dr. Birgit Friedmann-BetteSports medicine study lead
  • Prof. Dr. Sandy EngelhardtSite lead
Study coordination
Rebecca Hilbel
Patient recruitment
Dr. med. Samantha Fischer
Salmina José Guivala
Sports medicine
Anne Quermann
Julia Treiber
Nadine Boch

Mainz

University Medical Center Mainz · Preventive Medicine, Center for Cardiology

  • Univ.-Prof. Dr. Philipp WildSite lead
  • Prof. Dr. Dr. Perikles SimonSports medicine study lead
Study coordination
Silav Zeid
Project management
Julia Bollenbach
Patient recruitment
Dr. Maja Kahaly
Get in touch

Connect with Multi-dimensionAI

For scientific exchange, cooperation enquiries or further information about the project, contact the research team.

Contact the team